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A new advertising campaign for Philip Morris referred to research conducted by physicians

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Although the underlying mechanisms by which arsenic causes such oxidative damage are not yet fully understood, possible mechanisms could include inhibition of antioxidant enzymes such as superoxide dismutase (SOD) and catalase, interface with cellular antioxidant defense systems by reducing levels of intracellular antioxidants such as glutathione, inhibition of DNA repair mechanisms, and alterations in epigenetic processes [7]

Particularly when it's something that has been 'part of them' for most of their adult life." For some, quitting smoking can also mean letting go of old friends, she added